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CRISP1 cysteine rich secretory protein 1 [ Homo sapiens (human) ]

Gene ID: 167, updated on 2-Nov-2024

Summary

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Official Symbol
CRISP1provided by HGNC
Official Full Name
cysteine rich secretory protein 1provided by HGNC
Primary source
HGNC:HGNC:304
See related
Ensembl:ENSG00000124812 MIM:601193; AllianceGenome:HGNC:304
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ARP; AEGL1; HUMARP; CRISP-1; HEL-S-57; HSCRISP1D; HSCRISP1G
Summary
Fertilization consists of a sequence of specific cell-cell interactions culminating in the fusion of the sperm and egg plasma membranes. Recognition, binding, and fusion occur through the interaction of complementary molecules that are localized to specific domains of the sperm and egg plasma membranes. In the sperm, the postacrosomal region or equatorial segment is involved in sperm-egg plasma membrane fusion. The protein encoded by this gene is a member of the cysteine-rich secretory protein (CRISP) family. It is expressed in the epididymis, is secreted into the epididymal lumen, and binds to the postacrosomal region of the sperm head, where it plays a role in sperm-egg fusion. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2011]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

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See CRISP1 in Genome Data Viewer
Location:
6p12.3
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (49834257..49877096, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (49676220..49719057, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (49801970..49844809, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene phosphoglycerate kinase 2 Neighboring gene uncharacterized LOC101927020 Neighboring gene uncharacterized LOC101927048 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr6:49859209-49860408 Neighboring gene MPRA-validated peak5842 silencer Neighboring gene defensin beta 133 (pseudogene) Neighboring gene defensin beta 114

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. The less conserved metal-binding site in human CRISP1 remains sensitive to zinc ions to permit protein oligomerization. Sheng J, et al. Sci Rep, 2021 Mar 9. PMID 33750840, Free PMC Article
  2. Cysteine-rich secretory protein 1 in seminal plasma: potential biomarker for the distinction between obstructive and nonobstructive azoospermia. Légaré C, et al. Fertil Steril, 2013 Nov. PMID 23987519
  3. Vasectomy affects cysteine-rich secretory protein expression along the human epididymis and its association with ejaculated spermatozoa following vasectomy surgical reversal. Légaré C, et al. J Androl, 2010 Nov-Dec. PMID 20378925
  4. The molecular basis of sperm-oocyte membrane interactions during mammalian fertilization. Evans JP. Hum Reprod Update, 2002 Jul-Aug. PMID 12206465
  5. Molecular mechanisms involved in mammalian gamete fusion. Cuasnicú PS, et al. Arch Med Res, 2001 Nov-Dec. PMID 11750738

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The less conserved metal-binding site in human CRISP1 remains sensitive to zinc ions to permit protein oligomerization.
    Title: The less conserved metal-binding site in human CRISP1 remains sensitive to zinc ions to permit protein oligomerization.
  2. Epididymal CRISP1 mediates sperm-zona pellucida binding through its interaction with ZP3.
    Title: Human fertilization: epididymal hCRISP1 mediates sperm-zona pellucida binding through its interaction with ZP3.
  3. Seminal CRISP1 combined with neutral alpha glucosidase activity can potentially distinguish between obstructive and nonobstructive azoospermia.
    Title: Cysteine-rich secretory protein 1 in seminal plasma: potential biomarker for the distinction between obstructive and nonobstructive azoospermia.
  4. CRISP1 was in the seminal plasma of normal and vasovasostomized men, but not in that of vasectomized men. The soluble concentration of CRISP1 was significantly higher in the seminal plasma of vasovasostomized men as compared with that from normal men.
    Title: Vasectomy affects cysteine-rich secretory protein expression along the human epididymis and its association with ejaculated spermatozoa following vasectomy surgical reversal.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables calcium channel regulator activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in binding of sperm to zona pellucida IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in fusion of sperm to egg plasma membrane involved in single fertilization TAS
Traceable Author Statement
more info
 PubMed 
involved_in regulation of acrosome reaction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus HDA PubMed 

General protein information

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Preferred Names
cysteine-rich secretory protein 1
Names
AEG-like protein
AEG-related protein
acidic epididymal glycoprotein homolog
acidic epididymal glycoprotein-like 1
cysteine-rich secretory protein-1 delta
epididymis secretory protein Li 57

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001131.3 → NP_001122.2  cysteine-rich secretory protein 1 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001122.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the predominant transcript and encodes the longer isoform (1). Variants 1 and 3 encode the same isoform.
    Source sequence(s)
    AL359458
    Consensus CDS
    CCDS4931.1
    UniProtKB/Swiss-Prot
    B5BU98, O00698, P54107, Q13248, Q14082, Q96SF6
    UniProtKB/TrEMBL
    A0A0K0K1I1, A8K8Y2
    Related
    ENSP00000338276.4, ENST00000335847.9
    Conserved Domains (2) summary
    cd05383
    Location:39 → 177
    SCP_CRISP; SCP_CRISP: SCP-like extracellular protein domain, CRISP-like sub-family. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, which combine SCP with a ...
    pfam08562
    Location:195 → 249
    Crisp; Crisp

  2. NM_001205220.2 → NP_001192149.1  cysteine-rich secretory protein 1 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001192149.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) contains an alternate 5' terminal non-coding exon, thus differs in the 5' UTR compared to variant 1. Variants 1 and 3 encode the same isoform (1).
    Source sequence(s)
    AL359458, BC028577, X95237
    Consensus CDS
    CCDS4931.1
    UniProtKB/Swiss-Prot
    B5BU98, O00698, P54107, Q13248, Q14082, Q96SF6
    UniProtKB/TrEMBL
    A0A0K0K1I1, A8K8Y2
    Related
    ENSP00000427589.1, ENST00000505118.1
    Conserved Domains (2) summary
    cd05383
    Location:39 → 177
    SCP_CRISP; SCP_CRISP: SCP-like extracellular protein domain, CRISP-like sub-family. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, which combine SCP with a ...
    pfam08562
    Location:195 → 249
    Crisp; Crisp

  3. NM_170609.2 → NP_733758.1  cysteine-rich secretory protein 1 isoform 2 precursor

    See identical proteins and their annotated locations for NP_733758.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an exon in the 3' coding region compared to variant 1. This results in a frame-shift, early translation termination, and a shorter isoform (2, also known as CRISP-1 delta) compared to isoform 1.
    Source sequence(s)
    AL359458
    Consensus CDS
    CCDS4932.1
    UniProtKB/Swiss-Prot
    P54107
    Related
    ENSP00000425020.1, ENST00000507853.5
    Conserved Domains (1) summary
    cd05383
    Location:39 → 178
    SCP_CRISP; SCP_CRISP: SCP-like extracellular protein domain, CRISP-like sub-family. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, which combine SCP with a ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    49834257..49877096 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017010320.3 → XP_016865809.1  cysteine-rich secretory protein 1 isoform X1

    Conserved Domains (2) summary
    pfam08562
    Location:93 → 147
    Crisp; Crisp
    cl00133
    Location:1 → 75
    SCP; SCP: SCP-like extracellular protein domain, found in eukaryotes and prokaryotes. This family includes plant pathogenesis-related protein 1 (PR-1), which accumulates after infections with pathogens, and may act as an anti-fungal agent or be involved in ...

  2. XM_011514315.4 → XP_011512617.1  cysteine-rich secretory protein 1 isoform X1

    Conserved Domains (2) summary
    pfam08562
    Location:93 → 147
    Crisp; Crisp
    cl00133
    Location:1 → 75
    SCP; SCP: SCP-like extracellular protein domain, found in eukaryotes and prokaryotes. This family includes plant pathogenesis-related protein 1 (PR-1), which accumulates after infections with pathogens, and may act as an anti-fungal agent or be involved in ...

  3. XM_017010321.3 → XP_016865810.1  cysteine-rich secretory protein 1 isoform X1

    Conserved Domains (2) summary
    pfam08562
    Location:93 → 147
    Crisp; Crisp
    cl00133
    Location:1 → 75
    SCP; SCP: SCP-like extracellular protein domain, found in eukaryotes and prokaryotes. This family includes plant pathogenesis-related protein 1 (PR-1), which accumulates after infections with pathogens, and may act as an anti-fungal agent or be involved in ...

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    49676220..49719057 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054354384.1 → XP_054210359.1  cysteine-rich secretory protein 1 isoform X1

  2. XM_054354383.1 → XP_054210358.1  cysteine-rich secretory protein 1 isoform X1

  3. XM_054354385.1 → XP_054210360.1  cysteine-rich secretory protein 1 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P54107.1 GenPept UniProtKB/Swiss-Prot:P54107

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